REJEON PCL Filler Injection Anti-wrinkle hāpai a hoʻopaʻa
Ke Kumu o REJEON PCL
I nā makahiki he 20 i hala iho nei, ua hoʻomaikaʻi maikaʻi ʻia ko mākou ʻike ʻana i kekahi o nā wahi paʻakikī o ke kino o ke kanaka - ka maka - me ka ʻike ʻia ʻana o kekahi mau hanana anatomical hou.
I ka manawa like, he plethora o non-surgical
ua loaʻa nā kaʻina hana no ka mālama ʻana
nā hōʻailona o ka ʻelemakule a me ka hoʻihoʻi ʻana i ka ʻōpio
helehelena o ka helehelena. ʻO REJEON ka mua, a
I kēia manawa ʻo ia wale nō, collagen sti mulator i hana ʻia me nā microspheres polycaprolactone, e hāʻawi ana i kāna mau hoʻomaikaʻi maikaʻi ʻana. REJEON
'O nā waiwai kū'oko'a 'o ia ho'i, he koho i makemake 'ia no ka nui o nā ka'ina hana lole palupalu.
Hōʻuluʻulu manaʻo
Ka haku mele REJ EO N ,
7 0 % wai CMC
mea lawe gela3 0 % PCL
haku mele,hiki no
he hopena hoʻopiha koke
i hoʻokumu ʻia e CMC, a ukali ʻia e ka hoʻoulu ʻana i ke kolagen ponoʻī o ke kino ( neocollagenesis) .
Hoʻopili ʻia ka CMC mai 2 a 3
mahina ma hope o ka hoʻokomo ʻanaa ua pani ʻia e ka mea maʻi ponoʻī
kolagen (ʻano nui I) hoʻoulu ʻia e
PCL microspheres. Hiki ke bioresorbable nā microspheres o PCL.
Loaʻa iā REJEON kekahi mau hiʻohiʻona e lilo ia i koho maikaʻi ma ke ʻano he dermal filler:
①Ka hoʻopili ʻana o nā microspheres polymer, i loko o 1 mahina, a me ka scaffold collagen pili e pale i nā hopena ʻino hou aʻe mai ka hanana ʻana13
②ʻO ke ʻano collagen mau loa i loko o ka pūnaewele i hoʻopaʻa ʻia ʻo ia ka nui o ka 'mature' collagen scaffold o ka collagen type I5
a) ʻO ka emi ʻana o ka collagen type III ʻaʻole ia e hoʻoulu hou i ka pane inflammatory
③Hoʻopau ʻia ka hoʻohaʻahaʻa ʻana o nā mea REJEON e ka hydrolysis, waiho wale i ka wai a me ka carbon dioxide.
④No ka mea ʻoi aku ka nui o ka leo hope i loko o ka wahi i mālama ʻia ma mua o ka nui o Ellansé i hoʻopaʻa ʻia, ʻaʻohe koi e 'hoʻopā' i ka lāʻau.
a) ʻoi aku ka nui o ka leo hope ma mua o ka leo i hoʻopaʻa ʻia e 20-30% ma muli o ka hoʻokumu ʻia ʻana o nā fibre collagen type I11
⑤ʻO ka loaʻa ʻana o ʻelua mana o REJEON me nā lōʻihi like ʻole o ka hana, ʻo ia ka mea hiki ke hoʻohālikelike ʻia ka lōʻihi o ka hopena lapaʻau i ka mea maʻi.
koi
a) Loaʻa kēia ma ka hoʻololi ʻana i ka lōʻihi o nā kaulahao PCL, e ʻae ai i ka bioresorption hiki ke wānana, hoʻomalu a hoʻololi ʻia.
⑥Ua like ka ʻenehana lapaʻau me ka nānā ʻole i ka huahana REJEON i koho ʻia a) Same:
● Rheological waiwai
● ʻenehana
● Syringe
● Needle/cannula
REJEON PCL haku mele ʻokoʻa
Hoʻokumu ʻia ʻo REJEON PCL me kahi kūʻokoʻa, patent
hui o:
● 7 0 % carboxymethyl cellulose (CMC) - ka mea lawe gel
● 3 0 % polycaprolactone ( PCL ) microspheres ( Kiʻi 1 .4 ) 3 , 4 , 5
Hoʻopaʻa ʻia nā microspheres PCL
hoʻokuʻu homogeneous i ka CMC-based gel carrier. Loaʻa iā PCL a me CMC kahi ʻike biocompatibility maikaʻi a hōʻoia ʻia.
No Gemany mai ka REJEON PCL
NA MICROSPERA PCL
ʻO ka PCL he polyester lāʻau ʻawaʻawa ʻole, hana mua ʻia i ka makahiki 1930s4, ʻo ia hoʻi.
nani no ka hoʻohana ʻana i nā mea hoʻopihapiha dermal no ka maʻalahi o ka bioresorption; ua hoʻoheheʻe ʻia i ke kalapona ʻokikene a me ka wai i loko o ke kino5.
ʻO nā microspheres PCL i hoʻohana ʻia ma
Hoʻolālā ʻia ʻo RE JEON e hāʻawi
biocompatibility maikaʻi loa6 . He ili pahee ko lakou, a
kino poepoe a me ka nui o
ma kahi o 25–50 μm
He kūlana palekana maikaʻi loa ko PCL3 a ua hoʻohana ʻia ma ke kahua biomedical no nā makahiki ʻoi aku ma mua o 70 no ke ʻano o nā noi, mai nā sutures a hiki i nā ʻiʻo a me nā mea hoʻololi ʻia e ka paʻi 3D (Figure 1.6)4. Hoʻohana ʻia ia ma CE-marked a me US Food a
Drug Administration (FDA) - nā huahana i ʻae ʻia.
NA WAIWAI O CMC
ʻO CMC kahi mea kūlohelohe i loaʻa mai ka cellulose; ʻaʻole ia i hoʻopaʻa ʻia, a ʻaʻohe mea ʻawaʻawa. ʻO kāna mau waiwai ʻē aʻe (Figure 1.7)4 :
● He mea hoʻohana lāʻau lapaʻau i ʻike ʻia
● He hygroscopic
● Ua koho ʻia e ka FDA ma ke ʻano he palekana ( GRAS)
● Loaʻa ka resorption i loko o 2 - 3 mahina
ʻO nā pono nui o REJEON PCL Filler
ʻO REJEON PCL he microsphere kūʻokoʻa a kūpono hoʻi, me ka nui o ka nui e kū ana i nā kūlana palekana honua a me kahi papa maʻemaʻe e hiki ke hoʻoikaika mau i ka ulu ʻana o ka collagen.
Hoʻoulu ʻia ʻo Collagen e REJEON: Hōʻike ʻepekema
Ua loaʻa iā REJEON
hoao i ka holoholona
kumu hoʻohālike i hoʻokomo ʻia ai nā lākeke
ʻo REJEON S
(PCL-1) a i ʻole REJEON M (PCL-2) e noiʻi i ka neocollagenesis5.
ʻEiwa mahina ma hope o ka hoʻokomo ʻana o PCL-1,
ua hiki mai ka neocollagenesis a ua hoʻopau piha ʻia ka PCL microspheres o PCL-1 (Figure 1. 1 1) 5.
I kēia manawa, me PCL-2 ma 9 mau mahina,
he hoike no ka hookumu ana o
ʻano I a me ke ʻano III collagen a puni
PCL microspheres. Ma 2 1 mau mahina ma hope o ka hoʻokomo ʻia ʻana, aia mau nā PCL-2 microspheres i loko o ka ʻiʻo injected5.
Ma kahi noiʻi pilote o RE JEO N i loko o nā kānaka, ua kākau inoa ʻia nā mea maʻi e loaʻa iā Ellansé injected intradermally i loko o ka luakini.
ʻāpana9 . Hōʻike ʻia ka kānana histological o ka ʻiʻo i loaʻa mai nā biopsies
ka hoʻokumu ʻana o ka collagen a puni nā ʻāpana PCL injected (Figure 1. 12) 9, e kākoʻo ana i nā ʻike like i hōʻike ʻia ma mua.
ʻiʻo rabbit5 .
REJEON mea hana
Loaʻa iā REJEON ʻelua mau māhele o ka hana (Figure 1.9)1,4 :
● KaʻAnuʻu 1: Ma hope koke o ka hoʻokomo ʻana, hāʻawi ka ʻāpana CMC i ka leo pōkole,
e emi mālie ana ma luna o 2-3 mahina
● KaʻAnuʻu 2: Hoʻoulu ka PCL microspheres
neocollagenesis o nā ʻano I a me III collagen, me ka ʻoi aku ka hoʻomau ʻana o ka collagen type I
e piʻi mālie ana ka hale ma luna o 1 - 3 mahina a me nā microspheres PCL
komo i loko o ka collagen type I
scaffold. ʻO ka nui o ka collagen hopena
hoʻololi i ka piʻi ʻana o ka leo mua i hana ʻia e ka CMC gel
Hoʻoulu ʻia ka scaffold collagen e ka PCL
mau nā microspheres ma hope o ka hoʻihoʻi ʻia ʻana, e alakaʻi ana i ka piʻi ʻana o ka leo paʻa i ʻike ʻia me REJEON
He hopena maikaʻi nā REJEON PCL Filler
ʻO REJEON PCL Filler kahi mea hoʻopiha piha lōʻihi lōʻihi e hiki ke hoʻomaʻemaʻe i nā ala i waiho ʻia e ka manawa a hoʻihoʻi i kahi hiʻohiʻona a me ka ʻōpio i ka maka.
REJEON PCL FILLER MANAʻO KĀKINA
Manaʻo mākou e kaʻana like i kā mākou ʻike a
ʻike i ka manawa a pehea e hoʻokomo ai i ka r ej eon ma ka hana lapaʻau. Manaʻo wau e pōmaikaʻi ia i ka mea heluhelu e like me ia i hana ai iaʻu no nā makahiki he 10 i hala iho nei: hāʻawi i nā lāʻau lapaʻau palekana me ka hopena maikaʻi aʻe a me nā hopena lōʻihi. He mea paahana ko RE JEON i kaʻu hoʻomaʻamaʻa ʻana a ua hoʻolilo iaʻu i mea injector ʻoi aku ka maikaʻi! ”
Kauka Francisco de Melo
Kauka Hoʻopalekana, UAE
"ʻO RE JEON kaʻu mea hoʻopiha dermal punahele no
7 makahiki. Na kēia puke e kōkua iā ʻoe e aʻo i ka hoʻohana ʻana
RE JEON a aloha ʻoe iā ia. ”
Kauka Shang- Li Lin
Kauka dermatologist, Taiwan
"ʻO ka hoʻomaikaʻi ʻana i ke ʻano a me ka ʻili
maikaʻi mai ka RE JOE N 's unique
ʻAʻole kūlike ka neocollagenesis. ʻAʻole kānalua kekahi o nā mea hana maikaʻi loa no nā keʻena keʻokeʻo e makemake ana i ka hopena kiʻekiʻe a me ka palekana i kahi huahana injectable. Loaʻa iā REJ EO N ka
hiki ke hāʻawi i ka hoʻokiʻekiʻe lōʻihi a hoʻonui i ke ʻano o ka helehelena me hoʻokahi kau. ”
Kauka Ingrid Ló pez- Gehrke
Kauka dermatologist, Mekiko
"ʻOliʻoli nui wau i ka hoʻohana ʻana iā RE JEON ma muli o kāna hopena mele vol umi. Hiki i kēia ke emi
huahana e hoʻohana ʻia, a ma o ka hana maoli ʻana o ke ʻano collagen ʻano I, loaʻa ka mana maoli no ka ʻili
hana hou. He nui nā poʻe maʻi e haʻi mai iaʻu: ' ʻO ia ka manawa mua
Loaʻa iaʻu kahi mea mau', a i ʻole 'E nānā i ka maikaʻi o koʻu ʻili'. ʻOiaʻiʻo kaʻu mea hoʻopiha punahele. ”
Kauka Pierre Nicolau
Kauka ʻImi, Sepania
REJEON MAJOR MILESTONES
Ma hope o ka noiʻi nui a me ka hoʻomohala ʻana, a me ke kauka
hoʻāʻo, loaʻa iā REJEON ka palapala hōʻoia ISO 13485 Quality Management System ma
20081 (Kiʻi 1.2). I ka makahiki 2009, ua ʻae ʻia ka hōʻailona European Conformity (CE).
haawiia, alakai
i ka hoolaha holomua loa o
ka huahana ma UK, Kelemānia a me Sepania. Ua ukali ʻia nā hoʻolaha ʻē aʻe, me ka hoʻopaʻa inoa ʻana ma mua o 69
ʻāina ma 2018. Ma 2019, ka
10-makahiki makahiki o rejeon, oi
ma mua o 1 miliona syringes i kūʻai ʻia
puni honua. Akā ʻaʻole i pau ka moʻolelo kūleʻa ma laila, me ka hoʻomaka ʻana o kahi kahua hana hou ma Netherlands
hana ma 2020
REJEON PCL PRODUCT Detail
1ml/'āpana
E ʻae i ka hoʻopihapiha hoʻopili pilikino OEM
